Hipeksal may be available in the countries listed below.
Methenamine hippurate (a derivative of Methenamine) is reported as an ingredient of Hipeksal in the following countries:
International Drug Name Search
Domodin may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Detomidine hydrochloride (a derivative of Detomidine) is reported as an ingredient of Domodin in the following countries:
International Drug Name Search
Docusate Sodium (BAN, USAN) is also known as Dioctyl Sulfosuccinic Acid
Docusate Sodium (BAN, USAN) is known as Docusate in the US.
International Drug Name Search
Glossary
| BAN | British Approved Name |
| USAN | United States Adopted Name |
Neostigmina Braun may be available in the countries listed below.
Neostigmine metilsulfate (a derivative of Neostigmine) is reported as an ingredient of Neostigmina Braun in the following countries:
International Drug Name Search
In some countries, this medicine may only be approved for veterinary use.
In the US, Apomorphine (apomorphine systemic) is a member of the drug class dopaminergic antiparkinsonism agents and is used to treat Parkinson's Disease.
US matches:
BAN
G04BE07,N04BC07
0000058-00-4
C17-H17-N-O2
267
Dopamine agonist
Treatment of erectile dysfunction
Emetic
4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl
6αß-Aporphine-10,11-diol
International Drug Name Search
Glossary
| BAN | British Approved Name |
| BANM | British Approved Name (Modified) |
| DCF | Dénomination Commune Française |
| IS | Inofficial Synonym |
| OS | Official Synonym |
| PH | Pharmacopoeia Name |
Dicynone may be available in the countries listed below.
Etamsylate is reported as an ingredient of Dicynone in the following countries:
International Drug Name Search
Elaspol may be available in the countries listed below.
Sivelestat sodium (a derivative of Sivelestat) is reported as an ingredient of Elaspol in the following countries:
International Drug Name Search
Cetirizina Farmalider may be available in the countries listed below.
Cetirizine dihydrochloride (a derivative of Cetirizine) is reported as an ingredient of Cetirizina Farmalider in the following countries:
International Drug Name Search
Dolpasse retard may be available in the countries listed below.
Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Dolpasse retard in the following countries:
International Drug Name Search
Generic Name: acetaminophen and diphenhydramine (a SEET a MIN oh fen and DYE fen HYE dra meen)
Brand names: Anacin P.M. Aspirin Free, Coricidin Night Time Cold Relief, Excedrin PM, Excedrin PM Caplet, Excedrin PM Express Gels, Headache Relief PM, Legatrin PM, Mapap PM, Midol PM, Night Time Pain, Percogesic Extra Strength, Percogesic Original Strength, Tylenol Cold Relief Caplet, Tylenol Cold Relief Nighttime, Tylenol Cold Relief Nighttime Caplet, Tylenol Extra Strength PM, Tylenol Extra Strength PM Rapid Release Gelcaps, Tylenol Extra Strength PM Vanilla Caplet, Tylenol PM, Tylenol Sore Throat Nighttime, Unisom with Pain Relief, Bayer Select Max Strength Night Time Pain, Genapap PM, Sominex Pain Relief Formula, Tylenol Severe Allergy Caplet
Acetaminophen is a pain reliever and fever reducer.
Diphenhydramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
The combination of acetaminophen and diphenhydramine is used to treat headache, fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.
Acetaminophen and diphenhydramine may also be used for purposes not listed in this medication guide.
Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:
liver disease, cirrhosis, or a history of alcoholism;
a blockage in your digestive tract (stomach or intestines);
kidney disease;
cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis;
enlarged prostate or urination problems;
low blood pressure; or
if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up.
Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Do not take for longer than 7 days in a row. Stop taking the medicine and call your doctor if you still have a fever after 3 days of use, you still have pain after 7 days (or 5 days if treating a child), if your symptoms get worse, or if you have a skin rash, ongoing headache, or any redness or swelling.
See also: Acetaminophen and diphenhydramine dosage (in more detail)
Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.
Overdose symptoms may also include severe forms of some of the side effects listed in this medication guide.
chest pain, rapid pulse, fast or uneven heart rate;
confusion, hallucinations, severe nervousness;
tremor, seizure (convulsions);
easy bruising or bleeding, unusual weakness;
urinating less than usual or not at all; or
nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes).
Less serious side effects may include:
dizziness, drowsiness;
mild headache;
dry mouth, nose, or throat;
constipation;
blurred vision;
feeling nervous; or
sleep problems (insomnia);
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Insomnia:
Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.
Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Adult Dose for Pain:
Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.
Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Adult Dose for Headache:
Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.
Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Pediatric Dose for Insomnia:
Greater than or equal to 12 years:
Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.
Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Pediatric Dose for Pain:
Greater than or equal to 12 years:
Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.
Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Pediatric Dose for Headache:
Greater than or equal to 12 years:
Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime.
Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Tell your doctor about all other medicines you use, especially:
leflunomide (Arava);
topiramate (Topamax);
zonisamide (Zonegran);
diphenhydramine (Benadryl) applied to the skin;
an antibiotic, antifungal medicine, sulfa drug, or tuberculosis medicine;
an antidepressant;
birth control pills or hormone replacement therapy;
bladder or urinary medications;
blood pressure medication;
a bronchodilator;
cancer medicine;
cholesterol-lowering medications such as Lipitor, Niaspan, Zocor, Vytorin, and others;
gout or arthritis medications (including gold injections);
HIV/AIDS medication;
medication for nausea and vomiting, stomach ulcers, or irritable bowel syndrome;
medicines to treat psychiatric disorders;
an NSAID such as Advil, Aleve, Arthrotec, Cataflam, Celebrex, Indocin, Motrin, Naprosyn, Treximet, Voltaren, others; or
seizure medication.
This list is not complete and other drugs may interact with acetaminophen and diphenhydramine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
See also: acetaminophen and diphenhydramine side effects (in more detail)
In the US, Desogen (desogestrel/ethinyl estradiol systemic) is a member of the drug class contraceptives and is used to treat Abnormal Uterine Bleeding, Birth Control, Endometriosis, Gonadotropin Inhibition and Polycystic Ovary Syndrome.
US matches:
Desogestrel is reported as an ingredient of Desogen in the following countries:
Ethinylestradiol is reported as an ingredient of Desogen in the following countries:
International Drug Name Search
Anthelmin may be available in the countries listed below.
Mebendazole is reported as an ingredient of Anthelmin in the following countries:
International Drug Name Search
Lorazepam Induquimica may be available in the countries listed below.
Lorazepam is reported as an ingredient of Lorazepam Induquimica in the following countries:
International Drug Name Search
Awirol may be available in the countries listed below.
Aciclovir is reported as an ingredient of Awirol in the following countries:
International Drug Name Search
Couldespir may be available in the countries listed below.
Oxymetazoline hydrochloride (a derivative of Oxymetazoline) is reported as an ingredient of Couldespir in the following countries:
International Drug Name Search
Carvedilolo Germed may be available in the countries listed below.
Carvedilol is reported as an ingredient of Carvedilolo Germed in the following countries:
International Drug Name Search
Acide Aléndronique Ranbaxy may be available in the countries listed below.
Alendronic Acid sodium trihydrate (a derivative of Alendronic Acid) is reported as an ingredient of Acide Aléndronique Ranbaxy in the following countries:
International Drug Name Search
Domitral may be available in the countries listed below.
Nitroglycerin is reported as an ingredient of Domitral in the following countries:
International Drug Name Search
Dabur Mesna may be available in the countries listed below.
Mesna is reported as an ingredient of Dabur Mesna in the following countries:
International Drug Name Search
Generic Name: vitamin a (Oral route, Intramuscular route)
VYE-ta-min A
In the U.S.
Available Dosage Forms:
Therapeutic Class: Nutritive Agent
Pharmacologic Class: Vitamin A (class)
Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Vitamin A is needed for night vision and for growth of skin, bones, and male and female reproductive organs. In pregnant women vitamin A is necessary for the growth of a healthy fetus.
Lack of vitamin A may lead to a rare condition called night blindness (problems seeing in the dark), as well as dry eyes, eye infections, skin problems, and slowed growth. Your health care professional may treat these problems by prescribing vitamin A for you.
Some conditions may increase your need for vitamin A. These include:
In addition, infants receiving unfortified formula may need vitamin A supplements.
Vitamin A absorption will be decreased in any condition in which fat is poorly absorbed.
Increased need for vitamin A should be determined by your health care professional.
Claims that vitamin A is effective for treatment of conditions such as acne or lung diseases, or for treatment of eye problems, wounds, or dry or wrinkled skin not caused by lack of vitamin A have not been proven. Although vitamin A is being used to prevent certain types of cancer, some experts feel there is not enough information to show that this is effective, particularly in well-nourished individuals.
Injectable vitamin A is given by or under the supervision of a health care professional. Other forms of vitamin A are available without a prescription.
For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.
Vitamin A is found in various foods including yellow-orange fruits and vegetables; dark green, leafy vegetables; vitamin A-fortified milk; liver; and margarine. Vitamin A comes in two different forms, retinols and beta-carotene. Retinols are found in foods that come from animals (meat, milk, eggs). The form of vitamin A found in plants is called beta-carotene (which is converted to vitamin A in the body). Food processing may destroy some of the vitamins. For example, freezing may reduce the amount of vitamin A in foods.
Vitamins alone will not take the place of a good diet and will not provide energy. Your body needs other substances found in food, such as protein, minerals, carbohydrates, and fat. Vitamins themselves often cannot work without the presence of other foods. For example, small amounts of fat are needed so that vitamin A can be absorbed into the body.
The daily amount of vitamin A needed is defined in several different ways.
| Age or Condition | Form of Vitamin A | ||
| RE or mcg of Retinol | Amount in Units as Retinol | Amount in Units as a Combination of Retinol and Beta-carotene | |
| Infants and children Birth to 3 years | 375–400 | 1250–1330 | 1875–2000 |
| 4 to 6 years | 500 | 1665 | 2500 |
| 7 to 10 years | 700 | 2330 | 3500 |
| Teenage and adult males | 1000 | 3330 | 5000 |
| Teenage and adult females | 800 | 2665 | 4000 |
| Pregnant females | 800 | 2665 | 4000 |
| Breast-feeding females | 1200–1300 | 4000–4330 | 6000–6500 |
Note: Based on 1980 U.S. Recommended Dietary Allowances (RDAs) for vitamin A in the diet that is a combination of retinol and beta-carotene.
| Age or Condition | Form of Vitamin A | ||
| RE or mcg of Retinol | Amount in Units as Retinol | Amount in Units as a Combination of Retinol and Beta-carotene | |
| Infants and children Birth to 3 years | 400 | 1330 | 2000 |
| 4 to 6 years | 500 | 1665 | 2330 |
| 7 to 10 years | 700–800 | 2330–2665 | 3500 |
| Teenage and adult males | 1000 | 3330 | 5000 |
| Teenage and adult females | 800 | 2665 | 4000 |
| Pregnant females | 900 | 2665–3000 | 4000–4500 |
| Breast-feeding females | 1200 | 4000 | 6000 |
Note: Based on 1980 U.S. Recommended Dietary Allowances (RDAs) for vitamin A in the diet that is a combination of retinol and beta-carotene.
In the past, the RDA and RNI for vitamin A have been expressed in Units. This term Units has been replaced by retinol equivalents (RE) or micrograms (mcg) of retinol, with 1 RE equal to 1 mcg of retinol. This was done to better describe the two forms of vitamin A, retinol and beta-carotene. One RE of vitamin A is equal to 3.33 Units of retinol and 10 Units of beta-carotene. Some products available have not changed their labels and continue to be labeled in Units.
If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Problems in children have not been reported with intake of normal daily recommended amounts. However, side effects from high doses and/or prolonged use of vitamin A are more likely to occur in young children than adults.
Problems in older adults have not been reported with intake of normal daily recommended amounts. However, some studies have shown that the elderly may be at risk of high blood levels of vitamin A with long-term use.
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | X | Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit. |
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this dietary supplement, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this dietary supplement with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this dietary supplement. Make sure you tell your doctor if you have any other medical problems, especially:
This section provides information on the proper use of a number of products that contain vitamin a. It may not be specific to Palmitate-A. Please read with care.
If you miss taking a vitamin for one or more days there is no cause for concern, since it takes some time for your body to become seriously low in vitamins. However, if your health care professional has recommended that you take this vitamin, try to remember to take it as directed every day.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For individuals taking the oral liquid form of vitamin A:
If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Vitamin A is stored in the body; therefore, when you take more than the body needs, it will build up in the body. This may lead to poisoning and even death. Problems are more likely to occur in:
Remember that the total amount of vitamin A you get every day includes what you get from foods that you eat and what you take as a supplement.
High doses and/or prolonged use of vitamin A may cause bleeding from the gums; dry or sore mouth; or drying, cracking, or peeling of the lips.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Check with your doctor as soon as possible if any of the following side effects occur:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.
In the US, Didanosine (didanosine systemic) is a member of the drug class nucleoside reverse transcriptase inhibitors (NRTIs) and is used to treat HIV Infection and Nonoccupational Exposure.
US matches:
Rec.INN
J05AF02
0069655-05-6
C10-H12-N4-O3
236
Antiviral agent, HIV reverse transcriptase inhibitor
2',3'-Dideoxyinosine
International Drug Name Search
Glossary
| BAN | British Approved Name |
| DCF | Dénomination Commune Française |
| IS | Inofficial Synonym |
| OS | Official Synonym |
| PH | Pharmacopoeia Name |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
Artione may be available in the countries listed below.
Carvedilol is reported as an ingredient of Artione in the following countries:
International Drug Name Search
Denpru may be available in the countries listed below.
Protamine Sulfate is reported as an ingredient of Denpru in the following countries:
International Drug Name Search
Difenoxina may be available in the countries listed below.
Difenoxina (DCIT) is known as Difenoxin in the US.
International Drug Name Search
Glossary
| DCIT | Denominazione Comune Italiana |
Benclamid may be available in the countries listed below.
Glibenclamide is reported as an ingredient of Benclamid in the following countries:
International Drug Name Search
Class: Hemostatics
Brands: RiaSTAP
A lyophilized concentrate of highly purified fibrinogen (blood coagulation factor I) prepared from pooled human plasma from suitable donors.1
Used to control acute bleeding episodes in patients with congenital fibrinogen deficiency (i.e., afibrinogenemia [absence or extremely low concentrations of plasma fibrinogen], hypofibrinogenemia [reduced concentrations of plasma fibrinogen]); designated an orphan drug by FDA for use in this condition.1 2 3 4
Not indicated in patients with dysfibrinogenemia (presence of abnormal or dysfunctional fibrinogen).1
Monitor fibrinogen level.1 Target level is 100 mg/dL; maintain this level until hemostasis is obtained.1
Each single-use vial contains between 900–1300 mg of fibrinogen (human).1 The actual fibrinogen potency for each lot is indicated on the vial label.1
Administer by slow IV injection using a dedicated line.1
Reconstitute vial with 50 mL of sterile water for injection.1 Gently swirl until the lyophilized powder is completely dissolved.1 Do not shake the vial.1 The reconstituted solution should be colorless and clear to slightly opalescent and should be inspected visually for particulate matter; discard solution if cloudy or if particles are present.1
Maximum rate is 5 mL/minute.1
Individualize dosage based on extent of bleeding, laboratory test results, and clinical condition of the patient.1
Dosage is expressed in mg of fibrinogen and is based on weight.1 Administration of 70 mg/kg of fibrinogen (human) increased plasma concentration of fibrinogen by approximately 120 mg/dL in a pharmacokinetic study in 14 patients.1
When the baseline fibrinogen level is known, use the following formula:
Target fibrinogen level (mg/dL) - measured fibrinogen level (mg/dL) / 1.7 (mg/dL per mg/kg body weight) = mg of fibrinogen/body weight (in kg)
When the baseline fibrinogen level is not known, recommended dose is 70 mg/kg.1
When the baseline fibrinogen level is known, use the following formula:
Target fibrinogen level (mg/dL) - measured fibrinogen level (mg/dL) / 1.7 (mg/dL per mg/kg body weight) = mg of fibrinogen/body weight (in kg)
When the baseline fibrinogen level is not known, recommended dose is 70 mg/kg.1
No special population dosage recommendations at this time. 1
History of serious immediate hypersensitivity reactions (e.g., anaphylaxis) to fibrinogen (human) or any ingredient in the formulation.1
Allergic and/or hypersensitivity reactions may occur.1 Closely monitor for manifestations of hypersensitivity (e.g., hives, generalized urticaria, chest tightness, wheezing, hypotension, anaphylaxis).1 Immediately discontinue drug and administer appropriate treatment if hypersensitivity occurs.1
Thromboembolic events (e.g., MI, pulmonary embolism, DVT, arterial thrombosis) may occur.1 Weigh benefits of the drug against risk of thrombosis.1 Monitor for thrombosis.1
Potential vehicle for transmission of human viruses (e.g., HIV, hepatitis B virus [HBV], hepatitis C virus [HCV]) and other infectious agents.1
Improved donor screening and viral eliminating/reducing procedures have reduced, but not completely eliminated risk of pathogen transmission with plasma-derived preparations.1 Possibility still exists for disease transmission.1 Report any suspected infections to the manufacturer at 866-915-6958.1
Category C.1
Not studied in nursing women with congenital fibrinogen deficiency.1
Evaluated in a limited number of children ≤16 years of age.1
Experience in those ≥65 years of age insufficient to determine whether geriatric adults respond differently than younger adults.1
Fever, headache.1
Adults: Approximately 82.3 hours.1
Children <16 years of age: Approximately 69.9 hours.1
2–25°C.1 Do not freeze.1 Protect from light.1
Reconstituted vials may be stored at room temperature and used within 24 hours.1 Reconstituted solutions should not be frozen.1
Fibrinogen (human) is a highly purified preparation of fibrinogen derived from pooled human plasma.1 Fibrinogen is a substrate of thrombin, factor VIII, and plasmin.1 3 4 During the coagulation process, thrombin cleaves fibrinogen, catalyzing a series of steps that ultimately result in formation of a stable fibrin clot.1 3 4
Plasma used in the preparation of fibrinogen are screened for human viruses (e.g., hepatitis B virus [HBV], hepatitis C virus [HCV], HIV).1 Additional viral purification steps are employed to further reduce the risk of pathogen transmission.1
Risk of hypersensitivity reactions.1 Importance of informing clinician if hives, chest tightness, wheezing, hypotension, or anaphylaxis occur.1
Risk of blood clotting disorders; importance of contacting a clinician if any new or unusual symptoms of thrombosis occur (e.g., unexplained pleuritic, chest and/or leg pain or edema, hemoptysis, dyspnea, tachypnea, unexplained neurologic symptoms).1
Risk of transmission of certain viruses or CJD; careful screening and manufacturing process have reduced risk.1 Symptoms of viral infection include headache, fever, nausea, vomiting, weakness, malaise, diarrhea, and jaundice (hepatitis).1
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.1
Importance of informing patients of other important precautionary information.1 (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Parenteral | For injection, for IV use only | number of mg indicated on the label | RiaSTAP | CSL Behring |
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions September 2010. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
1. CSL Behring. RiaSTAP (fibrinogen concentrate [human]) prescribing information. Kankakee, IL; 2009 Jan.
2. Food and Drug Administration. Orphan designations pursuant to Section 526 of the Federal Food and Cosmetic Act as amended by the Orphan Drug Act (P.L. 97 414). Rockville, MD. From FDA web site. Accessed 2009 Aug 13.
3. Kreuz W, Meili E, Peter-Salonen K et al. Efficacy and tolerability of a pasteurised human fibrinogen concentrate in patients with congenital fibrinogen deficiency. Transfus Apher Sci. 2005; 32:247-53. [PubMed 15919240]
4. Kreuz W, Meili E, Peter-Salonen K et al. Pharmacokinetic properties of a pasteurised fibrinogen concentrate. Transfus Apher Sci. 2005; 32:239-46. [PubMed 15919241]
Rec.INN
G03FA15
0065928-58-7
C20-H25-N-O2
311
Progestin
(17α)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
17-Hydroxy-3-oxo-19-nor-17α-pregn-4,9-dien-21-carbonitrile (IUPAC)
17-Hydroxy-3-oxo-19-nor-17α-pregna-4,9-diene-21-nitrile (WHO)
17α-(Cyanomethyl)-17-hydroxy-13beta-methylgona-4,9-dien-3-one
17α-cyanomethyl-17beta-hydroxy-13beta-methylgona-4,9-dien-3-one
17-α-Cyanomethyl-17-beta-hydroxy-4,9-estradien-3-one
17-α-Cyanomethyl-17-beta-hydroxy-estra-4,9(10)-dien-3-one
19-Norpregna-4,9-diene-21-nitrile, 17-hydroxy-3-oxo-, (17α)- (USAN)
International Drug Name Search
Glossary
| DCF | Dénomination Commune Française |
| IUPAC | International Union of Pure and Applied Chemistry |
| IS | Inofficial Synonym |
| JAN | Japanese Accepted Name |
| OS | Official Synonym |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
| WHO | World Health Organization |
Difenac may be available in the countries listed below.
Diclofenac diethylamine (a derivative of Diclofenac) is reported as an ingredient of Difenac in the following countries:
Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Difenac in the following countries:
International Drug Name Search
Damixan may be available in the countries listed below.
Zolpidem tartrate (a derivative of Zolpidem) is reported as an ingredient of Damixan in the following countries:
International Drug Name Search
Lynoral may be available in the countries listed below.
Ethinylestradiol is reported as an ingredient of Lynoral in the following countries:
International Drug Name Search
Tilosina may be available in the countries listed below.
Tilosina (DCIT) is also known as Tylosin (Rec.INN)
International Drug Name Search
Glossary
| DCIT | Denominazione Comune Italiana |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
Monoparin may be available in the countries listed below.
Heparin sodium salt (a derivative of Heparin) is reported as an ingredient of Monoparin in the following countries:
International Drug Name Search
Desamix Neomicina may be available in the countries listed below.
Dexamethasone is reported as an ingredient of Desamix Neomicina in the following countries:
Neomycin sulfate (a derivative of Neomycin) is reported as an ingredient of Desamix Neomicina in the following countries:
International Drug Name Search
Aciclostad may be available in the countries listed below.
Aciclovir is reported as an ingredient of Aciclostad in the following countries:
International Drug Name Search
Dobutabag may be available in the countries listed below.
Dobutamine hydrochloride (a derivative of Dobutamine) is reported as an ingredient of Dobutabag in the following countries:
International Drug Name Search
Darzitil may be available in the countries listed below.
Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Darzitil in the following countries:
Sulbactam pivoxil (a derivative of Sulbactam) is reported as an ingredient of Darzitil in the following countries:
International Drug Name Search
Epirubicina may be available in the countries listed below.
Epirubicina (DCIT) is known as Epirubicin in the US.
International Drug Name Search
Glossary
| DCIT | Denominazione Comune Italiana |
Digitoxin AWD may be available in the countries listed below.
Digitoxin is reported as an ingredient of Digitoxin AWD in the following countries:
International Drug Name Search
Dafnegil may be available in the countries listed below.
Ciclopirox olamine (a derivative of Ciclopirox) is reported as an ingredient of Dafnegil in the following countries:
International Drug Name Search
Dolotor may be available in the countries listed below.
Ketorolac tromethamine (a derivative of Ketorolac) is reported as an ingredient of Dolotor in the following countries:
International Drug Name Search
In some countries, this medicine may only be approved for veterinary use.
Butorphanol is reported as an ingredient of Torbutrol in the following countries:
Butorphanol tartrate (a derivative of Butorphanol) is reported as an ingredient of Torbutrol in the following countries:
International Drug Name Search
Relieving symptoms of sinus congestion, runny nose, sneezing, and cough due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.
Tussal-ER Sustained-Release Tablets are a decongestant, antihistamine, and cough suppressant combination. It works by constricting blood vessels and reducing swelling in the nasal passages, The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing while the cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Tussal-ER Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Tussal-ER Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Tussal-ER Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Tussal-ER Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Tussal-ER Sustained-Release Tablets.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Tussal-ER side effects (in more detail)
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.
Store Tussal-ER Sustained-Release Tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tussal-ER Sustained-Release Tablets out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Tussal-ER Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
